Biopharmaceutics and Pharmacokinetics book, notes pdf - b pharmacy 3rd year (6th semester) - JNTUH

 Biopharmaceutics and Pharmacokinetics

Notes | Book | Syllabus | Previous Paper

B Pharmacy 3rd year (2nd sem) | 6th Semester | JNTUH




Unit - 1

Introduction to Biopharmaceutics
Absorption:
Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes, Distribution: Distribution of drugs Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs 




Unit - 2

Metabolism & Excretion:
Drug metabolism and basic understanding of metabolic pathways. Renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs
Bioavailability and Bioequivalence:
Objectives of bioavailability studies, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro, in-vivo correlations, bioequivalence studies, methods to enhance the bioavailability. 




Unit - 3

Pharmacokinetics:
Introduction to Pharmacokinetics models, Compartment models, non-compartment models, physiological models, One compartment open model. a. Intravenous Injection (Bolus) b. Intravenous infusion, extra vascular administrations, calculations of Ka, KE. From plasma and urinary excretion data  



Unit - 4
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Multicompartment models:
Two compartment open model. IV bolus

Multiple – Dosage Regimens:
a). Repititive Intravenous injections – One Compartment Open Model
b). Repititive Extravascular dosing – One Compartment Open model 



Unit - 5

Nonlinear Pharmacokinetics:
a. Introduction,
b. Factors causing non-linearity.
c. Michaelis-menton method of estimating parameters, Biotransformation of drugs




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